2%) typical

GERD symptoms, PD-0332991 in vivo and 1638 had both (81.3%). GERD tests found hiatus hernia (28.9%), esophagitis (49.1%), Barrett esophagus (7.1%) and abnormal acid reflux (58.7%). The total follow-up in not completed, however, we have reported several parts of our studies: Radiofrequency study for 505 patients from 2006 to 2008, Wheezing score significantly decreased (p < 0.01) from 7.83 to 3.07, cough from 6.77 to 2.85, heartburn from 5.31 to 1.79; Fundoplication study for 198 patients from 2008 to 2009, The score of heartburn, regurgitation, coughing, wheezing, shortness of breath, choking, and chest pain significantly decreased (P < 0.01) from 4.92, 4.98, 7.23, 7.50, 5.83, 5.94, and 4.92 to 1.62, 0.64, 2.79, 2.53, 1.37, 1.28 and 1.57, respectively. Conclusion: Radiofrequency and fundoplication are both effective for medication refractory ES, GERD evaluation and intervention are beneficial for refractory ES. Key Word(s): 1. GERD; 2. extraesophageal; 3. radiofrequency; 4. fundoplication; Presenting Author: ARIS ANTONINOUMALI PENA Additional Authors: ROMMELPARULAN ROMANO, ALBERTESTRADA AZD5363 nmr ISMAEL Corresponding Author: ARIS ANTONINOUMALI PENA Affiliations: University of Santo Tomas Hospital Objective: BACKGROUND Endoscopic dilation is a common procedure in the management of dysphagia in benign esophageal obstruction. However, there is a dearth of literature regarding long-term outcomes. OBJECTIVE Determine the

symptom improvement after dilatation and the frequency and interval between repeat dilatations among patients with benign esophageal obstruction. Methods: Consecutive patients who underwent endoscopic dilatation for benign esophageal obstruction from January 2001-September 2011 were included. Symptom improvement after dilatation was determined by phone interview and scored on a graded scale. Results: A total of 63 patients were included. Majority was female (61%) with mean age of 46.46 + 16.46. Majority (65.1%) was due to achalasia while the rest were due to acid/alkali Glutathione peroxidase ingestion (12.7%), gastroesophageal reflux disease (19.9%)

and other causes (3.2%). Patients with achalasia required a significantly less number of dilatation sessions compared with non-achalasia patients (1.32 + 0.545 vs. 2.78 + 3.077, p = 0.011) with a majority 73.2% requiring only 1 session as compared to 36.4% for non-achalasia patients (p = 0.011). Majority of achalasia patients had complete symptomatic relief after the 1st session 73.3% compared to only 37.5% for non-achalasia patients. There was no difference in the interval between the 1st and 2nd dilatation sessions in patients who required repeat dilatations (achalasia 44.54 + 80.00 wks vs. Non-achalasia 5.79 + 6.16; p = 0.525). Conclusion: Achalasia is the most common cause of benign esophageal obstruction. Achalasia patients often required only 1 dilatation session and achieved complete symptom relief more frequently compared to non-achalasia patients. Key Word(s): 1. Achalasia; 2. Dilatation; 3.