In case 1, the patient was a 33-year-old woman who had developed pale red papules on her face, especially around her eyes and lower jaw, approximately PFTα Apoptosis inhibitor 7 months previously. Examination of
a skin biopsy specimen revealed epithelioid cell granulomas accompanied by caseous necrosis, and a diagnosis of LMDF was made. The patient was treated successively with azithromycin, roxithromycin and minocycline hydrochloride, but there was no improvement. When we tried oral tranilast therapy, flattening of the papules was observed 2 weeks after the start of treatment, and by 1 month the papules had almost disappeared. In case 2, the patient was a 39-year-old man who had broken out in erythematous papules on both upper and lower eyelids, with some accompanied by scaling, 2 years before the initial examination. Pathological specimen revealed epithelioid cell granulomas accompanied by caseous necrosis, and a diagnosis of LMDF was made. There was no improvement when treated orally with minocycline hydrochloride or doxycycline hydrochloride, and treatment was switched to oral www.selleckchem.com/products/ly3039478.html tranilast therapy. After 1 month of treatment, the papules had almost disappeared. We concluded that oral tranilast therapy should be tried as a treatment for intractable LMDF.”
“Purpose: To evaluate glomerular injury in the rat model
during renal warm ischemia (WI), comparing artery and vein (AV) clamping with artery only (AO) clamping.
Materials and Methods: Twenty-four adult male rats underwent 60 minutes of renal WI in the left kidney. The animals were divided into three groups: AV clamping, Tipifarnib ic50 AO clamping, and Sham surgery. After 30 days, the animals were euthanized, and both kidneys were processed for paraffin embedding and stained with hematoxylin and eosin. Glomerular volume density (Vv[glom]), mean glomerular volume (MGV), and number of glomeruli per mm(3) (Nv[glom]) were evaluated in the renal cortex.
Results: The Vv[glom] was reduced in the left kidney (ischemic) when
compared with the right kidney in both AV and AO groups by 11.1% and 35.4%, respectively; however, the difference was significant only in the AV group. The Nv[glom] was reduced in the left kidney when compared with the right kidney in both AV and AO groups by 11.6% and 31.4%, respectively; nevertheless, the difference was significant only in the AV group. The MGV of left and right kidneys was the same in both Sham and AO groups and was diminished by 6.7% in the AV group-not significant.
Conclusion: AV clamping causes a significant decrease in the number of glomeruli in the rat model, while AO clamping reduces the glomerular number, but not significantly. To minimize renal injury, AO clamping may be preferred over AV clamping when WI is necessary in patients with previously compromised renal function.