In one-quarter of the recorded caudate neurons ridge tuning was found, where the region of increased activity, forming an elongated ridge of maximal sensitivity

parallel or angled to the spatial or the temporal frequency axis, indicating temporal (16%), spatial (5%) or speed (5%) tuning, respectively. The velocity preference of the ridge tuned caudate nucleus neurons is significantly lower than that of the peak tuned neurons. The peak tuned neuron could encode high velocities, while the ridge tuned neurons were responsible for the detection of moderate and lower velocities. Based upon our results, we suggest that the wide variety of spatio-temporal frequency response profiles might represent different functional neuronal groups within the caudate PF-4708671 nmr nucleus that subserve different behaviors to meet various environmental requirements. (C) 2010 Elsevier CX-6258 concentration Ireland Ltd. All rights reserved.”
“Objective: A robust release of endothelin-1 with subsequent endothelin-A subtype receptor activation occurs in patients after cardiac surgery requiring cardiopulmonary bypass. Increased endothelin-A subtype receptor activation has been identified in patients with poor left ventricular function (reduced ejection fraction). Accordingly, this study tested the hypothesis that a selective endothelin-A subtype receptor antagonist

administered perioperatively would favorably affect post-cardiopulmonary bypass hemodynamic profiles in patients with a preexisting poor left ventricular ejection Panobinostat fraction.

Methods: Patients (n = 29; 66 +/- 2 years) with a reduced left ventricular ejection fraction (37% +/- 2%) were prospectively randomized in a blinded fashion, at the time of elective coronary revascularization or valve replacement requiring cardiopulmonary bypass, to infusion of the highly selective and potent endothelin-A subtype receptor antagonist sitaxsentan at 1 or 2 mg/kg (intravenous bolus; n 9, 10 respectively) or vehicle (saline; n 10). Infusion of the endothelin-A subtype receptor antagonist/vehicle was performed immediately

before separation from cardiopulmonary bypass and again at 12 hours after cardiopulmonary bypass. Endothelin and hemodynamic measurements were performed at baseline, at separation from cardiopulmonary bypass (time 0), and at 0.5, 6, 12, and 24 hours after cardiopulmonary bypass.

Results: Baseline plasma endothelin (4.0 +/- 0.3 fmol/mL) was identical across all 3 groups, but when compared with preoperative values, baseline values obtained from age-matched subjects with a normal left ventricular ejection fraction (n 37; left ventricular ejection fraction>50%) were significantly increased (2.9 +/- 0.2 fmol/mL, P<.05). Baseline systemic (1358 +/- 83 dynes/sec/cm(-5)) and pulmonary (180 +/- 23 dynes/sec/cm(-5)) vascular resistance were equivalent in all 3 groups.