M. Ku-0059436 cell line Jablons); by the National Key Basic Research and Development (973) Program of China No. 2011CB910800 and No. 2012CB917304 (to H.M. Zhou); and by the China Natural Science Foundation No. 31170732 and No. 31270854 (to H.M. Zhou). References 1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ: Cancer statistics, 2008. CA Cancer J Clin 2008, 58:71–96.PubMedCrossRef
2. Campbell PJ, Stephens PJ, Pleasance ED, O’Meara S, Li H, Santarius T, Stebbings LA, Leroy C, Edkins S, Hardy C: Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet 2008, 40:722–729.PubMedCrossRef 3. Croce CM: Oncogenes and cancer. N Engl J Med 2008, 358:502–511.PubMedCrossRef 4. Mitelman F, Johansson B, Mertens F: Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer. Nat Genet 2004, 36:331–334.PubMedCrossRef 5. Nourse J, Mellentin JD, Galili N, Wilkinson
J, Stanbridge E, Smith SD, Cleary ML: Chromosomal translocation t(1;19) www.selleckchem.com/products/Fedratinib-SAR302503-TG101348.html results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell 1990, 60:535–545.PubMedCrossRef 6. Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT, Crouse V, Ma X, Buffler PA, Pine SR: Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proc Natl Acad Sci USA 2002, 99:15101–15106.PubMedCrossRef 7. High Content Screening Dedera DA, Waller EK, LeBrun DP, Sen-Majumdar A, Stevens ME, Barsh GS, Cleary ML: Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice. Cell 1993, 74:833–843.PubMedCrossRef 8. Kamps MP, Wright DD: Oncoprotein E2A-Pbx1 immortalizes a myeloid progenitor in primary marrow cultures without C1GALT1 abrogating its factor-dependence. Oncogene 1994, 9:3159–3166.PubMed 9. Monica K, LeBrun DP, Dedera DA, Brown R, Cleary
ML: Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable. Mol Cell Biol 1994, 14:8304–8314.PubMed 10. Fu X, Kamps MP: E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. Mol Cell Biol 1997, 17:1503–1512.PubMed 11. Hunger SP, Galili N, Carroll AJ, Crist WM, Link MP, Cleary ML: The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias. Blood 1991, 77:687–693.PubMed 12. Kamps MP, Look AT, Baltimore D: The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials. Genes Dev 1991, 5:358–368.PubMedCrossRef 13.