Study design. A retrospective review of patients who were treated for bisphosphonate-related osteonecrosis

of the jaws in the department of Oral and Maxillofacial Surgery during the period of 2002-2006 was performed. Seven patients, all IPI-145 nmr treated with the low- and medium-potency bisphosphonates clodronate or pamidronate, were selected as having an established bisphosphonate-related osteonecrosis of the jaws. Treatment consisted of sequestrectomy with curettage of the defect in combination with intravenous antimicrobial therapy.

Results. In 6 patients, signs and symptoms disappeared during follow-up which varied from 5 to 52 months. One patient had fewer complaints and developed a stable area of denuded bone.

Conclusion. From these data it is concluded that a protocol Selleck Batimastat consisting of thorough surgical debridement of the infected and necrotic tissue, rounding off of the affected bone, and primary closure leaving no dead space, supported by intravenous antimicrobial therapy for 1 week, followed by oral administration for 3 weeks, might lead to predictable good results in cases of low- and medium-potency bisphosphonate-related osteonecrosis of the jaws. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 107: e1-e7)”
“Amorphous silicon carbon

nitride (a-SiCN:H) films were synthesized using vapor transport-chemical vapor deposition technique. Poly(dimethylsilane) was used as a single source for both Si and C. NH(3) gas diluted in Ar is used as a source for nitrogen. The composition and bonding states are uniquely characterized with respect to

NH(3)/Ar ratio by Fourier transform infrared spectroscopy (FTIR) and x-ray photoelectron spectroscopy (XPS). Spectral deconvolution is used to extract the individual components of the FTIR and XPS spectra. For instance, the FTIR spectra show a remarkable drop in the intensity of Si H 89 mw – C vibration accompanied by the formation of further bonds including Si – N, C – N, C = N, C N, and N – H with increasing NH(3)/Ar ratio. Moreover, the XPS spectra show the existence of different chemical bonds in the a-SiCN:H films such as Si – C, Si – N, C – N, C = N, and C = C. Both FTIR and XPS data demonstrate that the chemical bonding in the amorphous matrix is more complicated than a collection of single Si – C Si – N, or Si – H bonds.”
“We examined the variation of the BMP4 gene in four Chinese indigenous cattle breeds and investigated the association of this polymorphism with body measurement traits. Using PCR-SSCP and DNA sequencing, a polymorphic microsatellite was detected in the third exon of the bovine BMP4 gene in 459 samples from four Chinese indigenous cattle breeds, Qinchuan, Luxi, Nanyang, and Jiaxian red. The two alleles were named A and B. Allele frequencies of BMP4-A/B in the four breeds were 0.939/0.061, 0.928/0.072, 0.929/0.071, and 0.938/0.062, respectively.